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Image Search Results
Journal: Journal of Biological Chemistry
Article Title: Inhibition of Glucosylceramide Synthase Does Not Reverse Drug Resistance in Cancer Cells
doi: 10.1074/jbc.m404466200
Figure Lengend Snippet: FIG. 1. Representative example of a cytotoxicity assay. Results are for the effect of the P-glycoprotein inhibitor XR9576 on the cytotox- icity of doxorubicin in NCI/AdRRES cells. Cytotoxicity assays were car- ried out as described under “Experimental Procedures.” Results are represented as (E, thin solid line) MCF7-wt untreated; (G, thick solid line) NCI/AdRRES untreated; ( , dashed line) NCI/AdRRES 25 nM XR9576. Results for MCF7-wt cells treated with 25 nM XR9576 were superimposable with those of untreated MCF7-wt cells (data not shown). Data represent the mean S.E. of at least four independent experiments.
Article Snippet: The FACSCalibur instrument was purchased with a grant from The Wellcome Trust (UK), Prism 4.0 was a kind gift from GraphPad, and
Techniques: Cytotoxicity Assay